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, Penghui Huang Zhejiang Lab, Research Institute of Intelligent Computing , Hangzhou 310012 , China MARA Key Laboratory of Soybean Biology (Beijing), State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences , Beijing 100081 , China Search for other works by this author on: Oxford Academic Xiaomei Zhang MARA Key Laboratory of Soybean Biology (Beijing), State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences , Beijing 100081 , China Search for other works by this author on: Oxford Academic Zhiyuan Cheng CAS Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China Search for other works by this author on: Oxford Academic Xu Wang Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences at Weifang , Weifang, Shandong 261325 , China Search for other works by this author on: Oxford Academic Yuchen Miao State Key Laboratory of Crop Stress Adaptation and Improvement, School of Life Sciences, Henan University , Kaifeng 475004 , China Search for other works by this author on: Oxford Academic Guowen Huang Department of Biological Sciences and Chemical Engineering, Hunan University of Science and Engineering , Yongzhou 425100, Hunan , China Search for other works by this author on: Oxford Academic Yong-Fu Fu MARA Key Laboratory of Soybean Biology (Beijing), State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences , Beijing 100081 , China Author for correspondence: fuyongfu@caas.cn (Y.F.F.), fengxianzhong@iga.ac.cn (X.F.) Search for other works by this author on: Oxford Academic Xianzhong Feng Zhejiang Lab, Research Institute of Intelligent Computing , Hangzhou 310012 , China CAS Key Laboratory of Soybean Molecular Design Breeding, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences , Changchun 130102 , China Author for correspondence: fuyongfu@caas.cn (Y.F.F.), fengxianzhong@iga.ac.cn (X.F.) Search for other works by this author on: Oxford Academic
https://orcid.org/0000-0003-0197-4846 The Plant Cell, Volume 36, Issue 2, February 2024, Pages 346–366, https://doi.org/10.1093/plcell/koad271
Published:
25 October 2023
Article history
Received:
17 July 2023
Accepted:
27 September 2023
Published:
25 October 2023
Corrected and typeset:
03 November 2023
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Penghui Huang, Xiaomei Zhang, Zhiyuan Cheng, Xu Wang, Yuchen Miao, Guowen Huang, Yong-Fu Fu, Xianzhong Feng, The nuclear pore Y-complex functions as a platform for transcriptional regulation of FLOWERING LOCUS C in Arabidopsis, The Plant Cell, Volume 36, Issue 2, February 2024, Pages 346–366, https://doi.org/10.1093/plcell/koad271
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Abstract
The nuclear pore complex (NPC) has multiple functions beyond the nucleo-cytoplasmic transport of large molecules. Subnuclear compartmentalization of chromatin is critical for gene expression in animals and yeast. However, the mechanism by which the NPC regulates gene expression is poorly understood in plants. Here we report that the Y-complex (Nup107–160 complex, a subcomplex of the NPC) self-maintains its nucleoporin homeostasis and modulates FLOWERING LOCUS C (FLC) transcription via changing histone modifications at this locus. We show that Y-complex nucleoporins are intimately associated with FLC chromatin through their interactions with histone H2A at the nuclear membrane. Fluorescence in situ hybridization assays revealed that Nup96, a Y-complex nucleoporin, enhances FLC positioning at the nuclear periphery. Nup96 interacted with HISTONE DEACETYLASE 6 (HDA6), a key repressor of FLC expression via histone modification, at the nuclear membrane to attenuate HDA6-catalyzed deposition at the FLC locus and change histone modifications. Moreover, we demonstrate that Y-complex nucleoporins interact with RNA polymerase II to increase its occupancy at the FLC locus, facilitating transcription. Collectively, our findings identify an attractive mechanism for the Y-complex in regulating FLC expression via tethering the locus at the nuclear periphery and altering its histone modification.
© The Author(s) 2023. Published by Oxford University Press on behalf of American Society of Plant Biologists. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
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